Retatrutide vs Tirzepatide
Retatrutide and Tirzepatide are compared here on the things that actually differ between them: what class each belongs to, what each acts on, how each is supplied and what each costs per milligram. Where the registry has no figure for one of them the row is left out rather than filled in.
Side by side
| Retatrutide | Tirzepatide | |
|---|---|---|
| Class | Triple GIP/GLP-1/glucagon receptor agonist | Dual GIP/GLP-1 receptor agonist |
| Acts on | A single peptide with agonist activity at three receptors: GIP, GLP-1 and glucagon. The glucagon component is what distinguishes it from dual agonists such as tirzepatide. | Agonist at both the GIP and GLP-1 receptors, a mechanism distinct from single-receptor GLP-1 agonists such as semaglutide. |
| Supplied as | Lyophilised vial, or pre-filled pen graduated in dial units. | Lyophilised vial or pre-filled pen. |
| Half-life | Long, supporting weekly intervals in clinical study design. | Approximately five days in published pharmacokinetics. |
| Storage | Refrigerated. Pens must not be frozen. Protect from light. | Refrigerated, protected from light. Not to be frozen. |
| Listings | 4 | 4 |
| Price from | £160 | £110 |
What actually differs
The clearest difference is class: Retatrutide is a triple GIP/GLP-1/glucagon receptor agonist, Tirzepatide is a dual GIP/GLP-1 receptor agonist. They are not supplied the same way. Retatrutide comes as a lyophilised vial, or pre-filled pen graduated in dial units, Tirzepatide as a lyophilised vial or pre-filled pen. Half-life differs as well: Long, supporting weekly intervals in clinical study design for Retatrutide against Approximately five days in published pharmacokinetics for Tirzepatide.
Quanta Pharma Retatrutide 30mg + Free BWin stock£160- SerenQ Retatrutide Penin stock£210
VLS Retatrutide Penin stock£220
Quanta Pharma Retatrutide 50mg + Free BWin stock£225
Quanta Pharma Tirzepatide 30mg + Free BWin stock£110- SerenQ Tirzepatidein stock£175
Quanta Pharma Tirzepatide 60mg + Free BWin stock£185
VLS Tirzepatide Penin stock£185
Availability checked 2026-09-09. The product page carries live stock.